Pathogenesis: Hepatitis C is the about common cause of chronic hepatitis in the world. The prevalence of hepatitis C virus infection is increasing public every day. The World Health Organization estimates that much than one hundred seventy million individuals throughout the world atomic number 18 infected with HCV. An estimated 1.8% of the macrocosm in the United States is positive for HCV antibodies; this pass judgment cor acts to an estimated 3.9 million persons with HCV infection nationwide. (OShea, 2011). Hepatitis C is a spherical, enveloped, single-stranded ribonucleic acid virus be to family Flaviviridae. In persons who argon infected, HCV may parent approximately a trillion radical viral particles for each one day in a steady state of viral replication. There are at least 6 inherited constitutions and more(prenominal) than 50 subtypes of the virus. The lifelike targets of HCV are hepatocytes and B lymphocytes. viral clearance is associated with the developme nt and perseveration of strong virus- detail responses by cytotoxic T lymphocytes and helper T cells. Findings from more late(a) studies suggest that 50% or more of the hepatocytes may be infected with HCV. Six major HCV genetic constitutions and legion(predicate) subtypes have been identified establish on molecular relatedness. molecular(a) differences between genotypes are relatively large.
genotypes 1, 2, and 3 have a worldwide distribution, while genotypes 4, 5, and 6 are localized to specific geographic locations. Genotype 1 is the close common genotype in the United States. HCV genotype 1, specially 1b, do es not respond to therapy as well as genotyp! es 2 and 3. Genotype 1 also may be associated with more severe liver-colored disease and a higher risk of hepatocellular carcinoma. Genotype 4 is the most prevalent genotype in Egypt, genotype 5 is engraft in South Africa, and genotype 6 is found in Southeast Asia. Currently, HCV is predominantly transmitted by percutaneous exposure to infected blood. In developed countries, most new HCV infections are related to intravenous drug abuse. The covert of blood...If you take to get a full essay, order it on our website: OrderCustomPaper.com
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